An air cooling system using an axial flow fan is generally applied in an electronic cabinet on shipboard. However, cases that apply a water cooling system or a mixture of water cooling and an air cooling system are gradually increased by applying the high-performance SBC (Single Board Computer) or DSP (Digital Signal Process), which has a high heating value. In this study, a structure borne noise reduction design for an electronic cabinet that applied a mixture of air and water cooling system was performed. First, the cooling system design was performed using a numerical analysis to secure a thermal stability, and then an electronic cabinet was produced. Next, considering the cooling performance, the reduction design for structure borne noise that causes an underwater radiated noise was performed using the experimental approach. The electronic cabinet, which has a thermal stability and meets the structure borne noise specifications, was finally developed.