Isothermal low cycle fatigue (LCF) behavior of a crystal nickel-based superalloy CMSX-4, a material for high-pressure turbine first stage rotor blade, was investigated at elevated temperatures. Strain-controlled LCF tests were performed under various test conditions, such as mechanical strain amplitude. Stress response and cyclic deformation were investigated, and equations of LCF life prediction were derived through the Coffin-Manson method. In addition, fatigue-induced fracture mechanism and microstructural evolution were investigated, using scanning electron microscopy (SEM). Results revealed that cyclic behavior of the CMSX-4 superalloy, was characterized by cyclic softening with increasing number of cycles at 800oC and 900oC. LCF of the CMSX-4 superalloy at 800oC and 900oC could be affected mainly by elastic damage in fatigue processing. Fatigue cracks were initiated in the surface oxide layer of the specimen. The plane of fracture surface was tilted toward <001> direction. The fatigue fracture mechanism was quasi-cleavage fracture at 800oC and 900oC. In all broken specimens, the γˊ phase morphology maintained cuboidal shape.