A pulsed-power source has the advantage of releasing a peak power over a short time interval. In this study, we implemented two types of such energy source, namely laser and dielectric break down power sources. We built the highpressure flow-output actuator utilizing such power sources in a micro-jet drug delivery system. We compared the jet speed from each power source and analyzed the drug penetration performance of the micro-jet injector. We found that hat the bubble growth rate caused by a dielectric breakdown power source per power input was three times faster than the laser power source. By using the micro-jet injector, we performed the insulin injection test using mouse models having diabetes mellitus to evaluate whether micro-jet injector has equivalent drug delivery performance when compared against conventional syringe-type injection.