This research developed a CAM S/W, which generates an adaptive 5-axis tool path, to optimize the quality of Direct Energy Deposition (DED) 3D printing. After reconstructing part shapes and generating printing paths in each shape, the path simulation including automatic collision detection was implemented. Productivity and printing quality were improved through equipment improvement and process optimization. In addition, high-quality parts with desirable physical and mechanical properties were produced by generating an adaptive 5-axis path specialized in the printing process that reflects various physical phenomena and monitoring results. Finally, the performance of CAM S/W was verified through the production of prototypes for industrial components.