The bone compression and the inertia from cochlear fluid or middle ear (ME) ossicles, are generally considered to be important components inducing bone-conducted (BC) hearing. To clarify the bone compression effect on the BC hearing caused by variation of Young’s modulus of skull, two different types of three-dimensional finite-element models were used in this study. The FE models were (1) Isolated cochlea model comprising ME and cochlea containing basilar membrane (BM) and (2) Head model comprising the isolated cochlea structure. The model was validated by comparison of cochlear responses such as BM velocities with those of otosclerosis patients’ clinical data. Additionally, results showed that the bone compression effects on a BC hearing is highly depended on the Young’s modulus of a skull. Also, the bone compression effects could be underestimated at low frequencies in temporal bone experiments, whereas the effects could be overestimated at high frequencies in cadaver experiments.