Slot-die coating technique has become a subject of interest owing to its mass and large area production characteristics. To date, numerous research on the fluid dynamics of coated solution and experimental decision of the coating conditions to improve quality of coated layer have been conducted. However, few studies have been done on the optimization of slot-die coater geometry owing to the high cost associated with its fabrication. In this study, we optimize the geometry of the slotdie coater using computational fluid dynamics. We used a statistical optimization technique (Box-Behnken design). In the optimization process, we determined the significant factors that affect the velocity variation of coated fluid in the transverse direction. An optimal geometry was derived using a desirability test which is generally used to evaluate the suitability of a selected geometry value based on the maximization of the velocity uniformity. Experimental results presenting the uniformity of the coated layer in the transverse direction improved from 4.7% to 1.4%.