The sanding device support bracket is part of the axle box and is one of the railway vehicles parts that must withstand extremely harsh environments. Conventional welded structure type brackets were cracked at welds during operation, requiring design changes. To minimize harsh environments and manufacturing errors, this review was conducted from the design stage, and design changes were made through several trial and error. In this paper, the optimal design was derived by performing topology optimization on the model designed and manufactured through trial and error and applied to the actual vehicle. The comparison of the existing model with the empirically designed model confirmed the improvement of the optimal design using the topology optimization. The optimized design was verified by the analysis and the vibration test of IEC 61373 was satisfied. The test parts based on the optimal design were applied to the actual vehicle and the performance was verified. In the optimum design process, the shape and material as well as the weight analysis were performed and finally the brackets were designed to be light in weight and improved in strength.