Recently, interbody fusion cage devices have been developed and used for lumbar reconstruction. Stand-alone cages reduce segmental mobility. In this study, we evaluated mechanical properties and biocompatibility of lumbar stand-alone cages. Evaluation of mechanical properties followed the ASTM F2077 standard that covers methods for static and fatigue testing. The sterility test was ensured by the ISO 11737-2. The extractable substances test was ensured by the Korea pharmacopoeia. Cytotoxicity of the specimen was assessed using MTT assay as recommended by the international standard guidelines, ISO 10993-Part 5 for in vitro testing.