This study aimed to determine mechanisms involved in the decrease of knee adduction moment (KAM) when waking with a contralateral cane without any constraint. Ten young subjects performed walking under two conditions: unassisted (no cane) or with a cane. After collecting data from the stance phase of the left foot, kinematic and kinetic data at early and late peaks of KAM were extracted for further analyses. When using a cane, early and late peaks of KAM decreased (p < 0.05) by 20.5% and 29.6%, respectively. Stepwise multiple regression analysis showed that the moment arm accounted for 59% and 95% of the variance of early and late KAM peaks, respectively. This reduction in moment arm occurred primarily due to lateral rotation of the GRF. Regarding the mechanism behind this, it could be due to the following: 1) by using a cane, the synthetic center of pressure shifted medially, which caused synthetic GRF to become more vertical than that of an unassisted walking and accordingly, and 2) the decrease of horizontal component of synthetic GRF reduced horizontal component of foot GRF, leading to lateral rotation of foot GRF. Understanding these mechanisms might help us improve effective use of canes.