With the advent of high-tech products, the need for ultra-precision machining has become increasingly necessary, along with the need for a jig center machining center capable of precision machining. A jig center maintains the accuracy of a jig borer, and also has an automatic tool changer like that of a machining center. It performs various machining functions in addition to hole machining and is the most precise and rigid machine tool. Various control methods and analytical techniques to improve machining accuracy are currently being developed in the field of ultra-precise large-scale machine tools. One relevant finding is that the degree of deformation varies depending on the weight of the machine tool as well as the ground conditions. It is therefore necessary to optimize ground conditions before installing the machine tools so as to improve the machining accuracy. The depth of concrete as well as the depth and diameter of grout were selected as variables. We developed the simulation case through structural analysis to consider the position of columns and tables. As a result of optimizing the foundation condition, it was found that the relative displacement error was reduced by up to 98% compared to the rigid foundation condition.