When the penetrator collides with the target, the penetrator has different penetrating characteristics and residual velocity after penetration, according to the geometry of the penetrator. In this study, we optimized the geometry of the penetrator using the artificial neural network and the genetic algorithm to derive the best penetration performance. The Latin hypercube sampling method was used to collect the sample data, Simulation for predicting the behavior of the penetrator was conducted with the finite cavity pressure method to generate the training data for the artificial neural network. Also, the optimal hyper parameter was derived by using the Latin hypercube sampling method and the artificial neural network was used as the fitness function of the genetic algorithm to optimize the geometry of the penetrator. The optimized geometry presented the deepest penetration depth.