The set-up of an injection molding process is a very complicated and time-consuming job because it is required to well determine a lot of variables closely related to products. Thus, the productivity of the set-up process mainly depends on operators' expertise and know-how. To solve the problem mentioned before, this research constructs a support system which helps operators determining the condition of the injection molding easily and systematically. The construction of the support system consists of the following four steps: 1)to determine the control variables which affect the target defect types, 2)to design and implement UI(user interface) using a scenario of set-up process, 3)to design and implement the search algorithms for the initial and optimal condition, and 4)to construct the embedded system which integrates the support system with the operating system of a plastic injection molding machine. The test experiments of some typical products are performed using the embedded system to verify the validity of the support system.