Abstract

Pharmacotherapy was mainly used to treat osteoporosis. However, some researches showed that pharmacotherapy could induce unexpected adverse effects. Some studies showed that whole body vibration affected beneficially osteoporosis. This paper studied the effect of whole body vibration for osteoporosis compared with the effect of pharmacotherapy.
10 female rats were used and allocated into 4 group, CON, SHAM, DRUG, and WHY. Rats except SHAM group were ovariectomised to induce osteoporosis. Rats in WHV group were stimulated in whole body vibration at magnitude of 1㎜^peak-peak and frequency 45㎐, for 8 weeks (30 min/day, 5 days/week). Rat in DRGU group was orally administered the Actonel (0.58㎎/㎏), for 8 weeks (5days/week). The 4^th lumbar in rats were scanned at a resolution of 35㎛ at baseline, before stimulation, and 8 weeks after stimulation by In-vivo micro computed tomography. For detecting and tracking changes of biomechanical characteristics (morphological and mechanical characteristics) in lumbar trabecuar bone of rats, structural parameters were measured and calculated from acquiring images and finite element analysis was performed.
In the results, loss of quantity and change of structure of trabecular bone in WBV group were smaller than those in both CON and SHAM groups. In addition, mechanical strength in WBV group was stronger than that in both CON and SHAM groups. In contrast, biomechanical characteristics in WBV group were similar with those in DRUG group.
These results showed that reasonable whole body vibration was likely to treat osteoporosis and be substituted partly for drug treatment.

• Keywords: Osteoporosis(골다공증),Whole body vibration(전신진동),Drug(약제),Morphological characteristics(형태학적인 특성),Mechanical characteristics(기계적인 특성)