This study investigated biomechanical response through the 3-dimensional virtual skeletal model developed and validated. Ten male subjects in standing posture were exposed to whole body vibrations and measured acceleration on anatomical of interest (head, 7th cervical, 10th thoracic, 4th lumbar, knee joint and bottom of the vibrator). Three dimensional virtual skeletal model and vibration machine were created by using BRG LifeMOD and MSC. ADAMS. The results of forward dynamic analysis were compared with results of experiment. The results showed that the accuracy of developed model was 73.2±19.2% for all conditions.