In the recent field of Machining, with the improving efficiency of processing, the index table is a key unit according to the increase of parts in available processing when working with the three axes at the same time. As an essential product of MCT, the index tables effect an influence on product quality of machined parts. Therefore, it is necessary to design the shape of index table with stability, high stiffness, lightweight structure. In this study, the optimal shape of index table was proposed using by design of experiment. The maximum displacement and stress analysis were carried out by using FEM software. The optimized shape was verified by using the statistical software. The results of shape optimization were confirmed that both displacement and stress were reduced in comparison with initial model.