The thermoforming process has been widely used to manufacture medium- and large-sized plastic parts because of the relatively low cost and high productivity, as compared with other plastic forming processes. One of current salient issues of thermoforming industries is the reduction of trial and error during the production of the thermoformed product. Hence, there is a significant increasing interest in the thermoforming analysis by the thermoforming industries. The goal of this paper is to investigate a methodology of the three-dimensional thermoforming analysis for medium- and large-sized plastic parts. There is a discussion about methodologies of thermoforming analysis, as well as material modeling, and three-dimensional finite element analysis. Furthermore, there is an examination, through case studies, about the applicability of the proposed methodology concerning the thermoforming analysis.