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JKSPE : Journal of the Korean Society for Precision Engineering

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Development of a Hybrid Composite Structure and Bioreactor for Enhanced Bone Regeneration in Dental Implants
Eun Chae Kim, Jun-Kyu Kang, Hun-Jin Jeong, So-Jung Gwak, Seung-Jae Lee
J. Korean Soc. Precis. Eng. 2025;42(9):695-702.
Published online September 1, 2025
DOI: https://doi.org/10.7736/JKSPE.025.086

Dental implant surgery usually takes over 6 to 9 months, with 3 to 6 months specifically allocated for osseointegration between the implant and the surrounding bone. To expedite this process, we developed an innovative hybrid composite structure and a bioreactor. This hybrid structure features an assembly-type implant combined with a 3D-printed polycaprolactone (PCL) scaffold. The implant was redesigned in a modular format to enable the insertion of a scaffold between components, facilitating bone-to-bone contact instead of metal-to-bone contact, which enhances osseointegration. The PCL scaffold was coated with polydopamine (PDA) to improve cell adhesion. Additionally, a bioink that mimics bone composition, consisting of type I collagen and nano-hydroxyapatite (nHA), was incorporated into the scaffold. To support cell maturation within the scaffold, we developed a hydrostatic pressure bioreactor system that applies uniform compressive stress to complex 3D structures. We assessed cell viability in the scaffold using the CCK-8 assay, and SEM imaging confirmed the effectiveness of the PDA coating. Furthermore, we evaluated osteogenic differentiation through ALP activity and calcium quantification assays under both static and dynamic stimulation conditions.

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Article
New Fabrication Method of Bio-Ceramic Scaffolds Based on Mould using a FDM 3D Printer
Min-Woo Sa, Seung Hyeok Choi, Jong Young Kim
J. Korean Soc. Precis. Eng. 2018;35(10):957-963.
Published online October 1, 2018
DOI: https://doi.org/10.7736/KSPE.2018.35.10.957
Scaffolds for bone tissue engineering (BTE) should accomplish appropriate mechanical, cell interaction, and new bone ingrowth properties. Among calcium phosphate (CaP) based bio-ceramics used for preparing scaffolds, biphasic calcium phosphate (BCP) is attracting great interest for fabricating BTE scaffolds owing to its excellent biocompatibility and osteoconductivity. Fused deposition modeling (FDM) is an additive manufacturing technology commonly used for modeling, prototyping, and production applications. It is one of techniques used for 3D printing. The main purpose of this study was to develop new fabrication process of BCP scaffolds based on extrusion moulding using a 3D printer. Through the 3D printer, we showed new fabrication process for making scaffold mould and extrusion device parts that could be combined with tension-compression test machine. Line width, pore size, and porosity of these fabricated BCP scaffolds were measured and calculated. Mechanical properties and cell proliferation results of these BCP scaffolds were then evaluated.

Citations

Citations to this article as recorded by  Crossref logo
  • Development of machine learning models for material classification and prediction of mechanical properties of FDM 3D printing outputs
    Su-Hyun Kim, Ji-Hye Park, Ji-Young Park, Seung-Gwon Kim, Young-Jun Lee, Joo-Hyung Kim
    Journal of Mechanical Science and Technology.2025; 39(2): 541.     CrossRef
  • A Study on the Optimization of Mold Conditions for Fabrication of Bio-ceramic Scaffold via a FDM 3D Printer
    Min-Woo Sa, Jong Young Kim
    Journal of the Korean Society of Manufacturing Process Engineers.2024; 23(1): 42.     CrossRef
  • 3D printing of Hollow Biocompatible Ceramic Scaffold by Material Deposition and Volumetric Shrinkage
    Seok Kim
    Journal of the Korean Society of Manufacturing Technology Engineers.2019; 28(1): 31.     CrossRef
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